[HTML][HTML] ICOS+ Tregs: A Functional Subset of Tregs in Immune Diseases
DY Li, XZ Xiong - Frontiers in immunology, 2020 - frontiersin.org
Recent studies have reported the pathological effect of ICOS+ T cells, but ICOS signals also
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
widely participate in anti-inflammatory responses, particularly ICOS+ regulatory T (Treg) …
Joint probabilistic modeling of single-cell multi-omic data with totalVI
The paired measurement of RNA and surface proteins in single cells with cellular indexing
of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to …
of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to …
[HTML][HTML] Regulatory T cell stability and plasticity in atherosclerosis
AJ Ali, J Makings, K Ley - Cells, 2020 - mdpi.com
Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …
Resident regulatory T cells reflect the immune history of individual lymph nodes
Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …
The beta cell-immune cell interface in type 1 diabetes (T1D)
Background T1D is an autoimmune disease in which pancreatic islets of Langerhans are
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
infiltrated by immune cells resulting in the specific destruction of insulin-producing islet beta …
Function, failure, and the future potential of Tregs in type 1 diabetes
M Bettini, ML Bettini - Diabetes, 2021 - Am Diabetes Assoc
Critical insights into the etiology of type 1 diabetes (T1D) came from genome-wide
association studies that unequivocally connected genetic susceptibility to immune cell …
association studies that unequivocally connected genetic susceptibility to immune cell …
CD4 T cells reactive to hybrid insulin peptides are indicators of disease activity in the NOD mouse
RL Baker, BL Jamison, TA Wiles, RS Lindsay… - Diabetes, 2018 - Am Diabetes Assoc
We recently established that hybrid insulin peptides (HIPs), formed in islet β-cells by fusion
of insulin C-peptide fragments to peptides of chromogranin A or islet amyloid polypeptide …
of insulin C-peptide fragments to peptides of chromogranin A or islet amyloid polypeptide …
[HTML][HTML] The Amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
Conventional immunosuppressive functions of CD4+ Foxp3+ regulatory T cells (Tregs) in
type 1 diabetes (T1D) pathogenesis have been well described, but whether Tregs have …
type 1 diabetes (T1D) pathogenesis have been well described, but whether Tregs have …
CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation
Immature T cells undergo a process of positive selection in the thymus when their new T cell
receptor (TCR) engages and signals in response to self-peptides. As the T cell matures, a …
receptor (TCR) engages and signals in response to self-peptides. As the T cell matures, a …
Position β57 of IAg7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
L Gioia, M Holt, A Costanzo, S Sharma, B Abe… - Science …, 2019 - science.org
The class II region of the major histocompatibility complex (MHC) locus is the main
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …
contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid …