P66shc is a gene that regulates the level of reactive oxygen species (ROS), apoptosis
induction, and lifespan in mammals. Mice knocked out for p66shc have a lifespan~ 30 …

Shc (Src homology and collagen homology) proteins are considered prototypical signalling
adaptors in mammalian cells. Consisting of four unique members, ShcA, B, C and D, and …

Malignant melanoma is an aggressive cancer known for its notorious resistance to most
current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the …

Background: Salivary adenoid cystic carcinoma (ACC) is an insidious slow-growing cancer
with the propensity to recur and metastasise to distant sites. Basal-like breast carcinoma …

Abstract Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a
slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to …

The identification of genes maintaining cancer growth is critical to our understanding of
tumorigenesis. We report the first in vivo genetic screen of patient-derived tumors, using …

Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic
susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing …

Purpose: Although the existence of cancer stem cells (CSC) in adenoid cystic carcinoma
(ACC) has been proposed, lack of assays for their propagation and uncertainty about …

Infantile hemangioma (IH) is the most prevalent type of vascular tumor in infants. The
pathophysiology of IH is unknown. The tissue structure and physiology of two-dimensional …

Abstract MEMO1 (mediator of ErbB2-driven cell motility 1) regulates HER2-dependent cell
migration. Increased MEMO1 expression is associated with cancer aggressiveness. Here …