Eukaryotic DNA-binding proteins operate in the context of chromatin, where nucleosomes
are the elementary building blocks. Nucleosomal DNA is wrapped around a histone core …

Early studies established that transcription initiates within an approximately 50bp DNA
segment capable of nucleating the assembly of RNA polymerase II (Pol II) and associated …

DNA in cells is predominantly B-form double helix. Though certain DNA sequences in vitro
may fold into other structures, such as triplex, left-handed Z form, or quadruplex DNA, the …

We determined genome-wide nucleosome occupancies in mouse embryonic stem cells and
their neural progenitor and embryonic fibroblast counterparts to assess features associated …

RNA-mediated transcriptional silencing prevents deleterious effects of transposon activity
and controls the expression of protein-coding genes. It involves long noncoding RNAs …

Chromatin organization and composition impart sophisticated regulatory features critical to
eukaryotic genomic function. Although DNA sequence-dependent histone octamer binding …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) has become
the preferred method for mapping chromatin accessibility due to its time and input material …

Background Histone post-translational modifications (HPTMs) including acetylation and
methylation have been recognized as playing a crucial role in epigenetic regulation of plant …

Postmitotic neurons are subject to a vast array of environmental influences that require the
nuclear integration of intracellular signaling events to promote a wide variety of neuroplastic …

Nucleosome positioning can alter the accessibility of DNA-binding proteins to their cognate
DNA elements, and thus its precise control is essential for cell identity and function …