Exposure to stress during critical periods in development can have severe long-term
consequences, increasing overall risk on psychopathology. One of the key stress response …

Vulnerability to emotional disorders including depression derives from interactions between
genes and environment, especially during sensitive developmental periods. Adverse early …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

C affect brain functioning through both delayed, genomic and rapid, non-genomic
mechanisms. The latter mode of action was long known but only in recent years the …

BackgroundCortisol plays a multifaceted role in major depression disorder (MDD). Diurnal
rhythms are disturbed, there is increased resistance to the feedback action of …

High-dose corticosteroids have been reported to reduce symptoms of acute stress and post-
traumatic stress in polytrauma patients and in animal studies. The underlying mechanism of …

Early life stress increases the risk for developing stress-related pathologies later in life.
Recent studies in rats suggest that mild early life stress, rather than being overall …

The natural complexity of the brain, its hierarchical structure, and the sophisticated
topological architecture of the neurons organized in micronetworks and macronetworks are …

Stress affects the hippocampus, a brain region crucial for memory. In rodents, acute stress
may reduce density of dendritic spines, the location of postsynaptic elements of excitatory …

Learning and memory processes carried out within the hippocampus are influenced by
stress in a complex manner, and the mechanisms by which stress modulates the physiology …