Applications of multi‐omics analysis in human diseases

C Chen, J Wang, D Pan, X Wang, Y Xu, J Yan… - MedComm, 2023 - Wiley Online Library
Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

7-Dehydrocholesterol dictates ferroptosis sensitivity

Y Li, Q Ran, Q Duan, J Jin, Y Wang, L Yu, C Wang… - Nature, 2024 - nature.com
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …

DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

P Qu, O Rom, K Li, L Jia, X Gao, Z Liu, S Ding, M Zhao… - Cell metabolism, 2023 - cell.com
Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy
approved. A major hurdle in NASH drug development is the poor translatability of preclinical …

Wekemo Bioincloud: A user‐friendly platform for meta‐omics data analyses

Y Gao, G Zhang, S Jiang, YX Liu - Imeta, 2024 - Wiley Online Library
The increasing application of meta‐omics approaches to investigate the structure, function,
and intercellular interactions of microbial communities has led to a surge in available data …

Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia

WY Cheng, JF Li, YM Zhu, XJ Lin… - Proceedings of the …, 2022 - National Acad Sciences
The current classification of acute myeloid leukemia (AML) relies largely on genomic
alterations. Robust identification of clinically and biologically relevant molecular subtypes …

Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition

W Chen, Y Zhang, Z Wang, M Tan, J Lin… - Frontiers in …, 2023 - frontiersin.org
Reperfusion is essential for ischemic myocardium but paradoxically leads to myocardial
damage that worsens cardiac functions. Ferroptosis often occurs in cardiomyocytes during …

Genetic factors of grain cadmium concentration in Polish wheat (Triticum polonicum L.)

Y Cheng, R Liu, T Yang, S Yang, J Chen… - Plant …, 2024 - academic.oup.com
Wheat (Triticum aestivum L.) is one of the most important crops worldwide and a major
source of human cadmium (Cd) intake. Limiting grain Cd concentration (Gr_Cd_Conc) in …

Lysimachia christinae polysaccharide attenuates diet-induced hyperlipidemia via modulating gut microbes-mediated FXR–FGF15 signaling pathway

YF Zhou, J Nie, C Shi, WW Zheng, K Ning… - International Journal of …, 2023 - Elsevier
Polysaccharides are one of the most abundant and active components of Lysimachia
christinae (L. christinae), which is widely adopted for attenuating abnormal cholesterol …

[HTML][HTML] Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid …

S Xu, CY Chuang, CL Hawkins, P Hägglund… - Redox Biology, 2023 - Elsevier
Peroxynitrous acid/peroxynitrite (ONOOH/ONOO−) is a powerful oxidizing/nitrating system
formed at sites of inflammation, which can modify biological targets, and particularly …

Single‐Cell RNA Sequencing and Spatial Transcriptomics Reveal Pathogenesis of Meningeal Lymphatic Dysfunction after Experimental Subarachnoid Hemorrhage

X Wang, A Zhang, Q Yu, Z Wang, J Wang… - Advanced …, 2023 - Wiley Online Library
Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke with high mortality and
disability rate. Meningeal lymphatic vessels (mLVs) are a newly discovered intracranial fluid …