The heart is a dynamic organ capable of significant architectural remodeling, cellular
adaptations, and molecular reprogramming following both physiologic and pathologic …

Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …

Garlic-derived organosulfides (OSCs) including diallyl trisulfide (DATS) are highly effective
in affording protection against chemically induced cancer in animals. Evidence is also …

p38α mitogen-activated protein (MAP) kinase is a broadly expressed signaling molecule that
participates in the regulation of cellular responses to stress as well as in the control of …

The antiapoptotic role of Bcl-2 can be regulated by its phosphorylation in serine and
threonine residues located in a nonstructured loop that links BH3 and BH4 domains. p38 …

The nerve growth factor (NGF) belongs to the neurotrophin family and induces its effects
through activation of 2 distinct receptor types: the tropomyosin-related kinase A (TrkA) …

Aldehyde dehydrogenase 2 (ALDH2) has both dehydrogenase and esterase activity; its
dehydrogenase activity is closely related to the metabolism of aldehydes produced under …

Nerve growth factor (NGF) and other members of the neurotrophin family are critical for the
survival and differentiation of neurons and have been implicated in the pathophysiology of …

Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the clonal expansion of
malignant plasma cells and is frequently associated with chromosomal translocations …

Increasing evidence suggests that c-Jun N-terminal kinase (JNK) is an important kinase
mediating neuronal apoptosis in brain ischemia. To further study the roles of JNK activation …