Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

A recent study with Ca++-sensitive-dyes in neurons in whole DRGs (Table 5) found that
much lower percentages of nociceptors were polymodal-nociceptors (PMNs)(Emery et al …

Viscera receive innervation from sensory ganglia located adjacent to multiple levels of the
brainstem and spinal cord. Here we examined whether molecular profiling could be used to …

Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are
presumed to be nociceptors and respond to noxious input in a graded manner. However …

Mechanistic theories of itch are based on neuronal specificity, stimulus intensity, and
temporal or spatial discharge patterns. Traditionally, these theories are conceptualized as …

Single cell sequencing has provided unprecedented information about the transcriptomic
diversity of somatosensory systems. Here, we describe a simple and versatile in situ …

PDL1 is a protein that induces immunosuppression by binding to PD1 expressed on
immune cells. In line with historical studies, we found that membrane-bound PD1 expression …

Ketogenic diets are emerging as protective interventions in preclinical and clinical models of
somatosensory nervous system disorders. Additionally, dysregulation of succinyl-CoA 3 …

Skin-resident mast cells (MCs) and cutaneous sensory neurons both play crucial roles in
microbial‒host defense and inflammatory diseases. MCs can be directly activated by …

Background Chronic postsurgical pain (CPSP) in children remains an important problem
with no effective preventive or therapeutic strategies. Recently, genomic underpinnings …