[HTML][HTML] Human D-amino acid oxidase: structure, function, and regulation
D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …
[HTML][HTML] Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids …
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids …
Molecular dynamics simulations: principles, methods, and applications in protein conformational dynamics
AK Padhi, M Janežič, KYJ Zhang - Advances in protein molecular and …, 2022 - Elsevier
Molecular dynamics (MD) is a powerful computational technique that allows us to simulate
the interactions of atoms and molecules of a system over a specific period of time through …
the interactions of atoms and molecules of a system over a specific period of time through …
Characterization of E121K mutation of D-amino acid oxidase–insights into mechanisms leading to amyotrophic lateral sclerosis
D-amino acid oxidase (DAO) maintains the intracellular d-serine level which modulates the
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …
Enhancing Electrochemical Biosensor Selectivity with Engineered d-Amino Acid Oxidase Enzymes for d-Serine and d-Alanine Quantification
d-Amino acid oxidase (DAAO) enzymes bind a range of d-amino acids with variable affinity.
As such, the design of selective DAAO-based enzymatic biosensors remains a challenge for …
As such, the design of selective DAAO-based enzymatic biosensors remains a challenge for …
[HTML][HTML] Focus on the role of d-serine and d-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS)
NR Kondori, P Paul, JP Robbins, K Liu… - Frontiers in molecular …, 2018 - frontiersin.org
We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W,
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …
Structure–function relationships in human D-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms
M Katane, R Kanazawa, R Kobayashi, M Oishi… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abstract d-Aspartate oxidase (DDO) is a degradative enzyme that is stereospecific for the
acidic amino acid d-aspartate, an endogenous agonist of the N-methyl-d-aspartate (NMDA) …
acidic amino acid d-aspartate, an endogenous agonist of the N-methyl-d-aspartate (NMDA) …
[HTML][HTML] A detailed mechanism of the oxidative half-reaction of D-amino acid oxidase: another route for flavin oxidation
DJ Kiss, GG Ferenczy - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
D-Amino acid oxidase (DAAO) is a flavoenzyme whose inhibition is expected to have
therapeutic potential in schizophrenia. DAAO catalyses hydride transfer from the substrate to …
therapeutic potential in schizophrenia. DAAO catalyses hydride transfer from the substrate to …
[HTML][HTML] Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access
K Subramanian, A Góra, R Spruijt, K Mitusińska… - PLoS …, 2018 - journals.plos.org
D-amino acid oxidase (DAAO) degrades D-amino acids to produce α-ketoacids, hydrogen
peroxide and ammonia. DAAO has often been investigated and engineered for industrial …
peroxide and ammonia. DAAO has often been investigated and engineered for industrial …
Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase
The D-amino acid oxidase protein modulates neurotransmission by controlling the levels of
D-serine, a co-agonist of N-methyl-D-aspartate receptors. Mutations in the DAO gene have …
D-serine, a co-agonist of N-methyl-D-aspartate receptors. Mutations in the DAO gene have …