[HTML][HTML] Human D-amino acid oxidase: structure, function, and regulation

L Pollegioni, S Sacchi, G Murtas - Frontiers in Molecular Biosciences, 2018 - frontiersin.org
D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …

[HTML][HTML] Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies

S Sacchi, P Cappelletti, G Murtas - Frontiers in molecular biosciences, 2018 - frontiersin.org
The stereoselective flavoenzyme D-amino acid oxidase (DAAO) catalyzes the oxidative
deamination of neutral and polar D-amino acids producing the corresponding α-keto acids …

Molecular dynamics simulations: principles, methods, and applications in protein conformational dynamics

AK Padhi, M Janežič, KYJ Zhang - Advances in protein molecular and …, 2022 - Elsevier
Molecular dynamics (MD) is a powerful computational technique that allows us to simulate
the interactions of atoms and molecules of a system over a specific period of time through …

Characterization of E121K mutation of D-amino acid oxidase–insights into mechanisms leading to amyotrophic lateral sclerosis

U Dave, S Khan, J Gomes - Biochimica et Biophysica Acta (BBA)-Proteins …, 2023 - Elsevier
D-amino acid oxidase (DAO) maintains the intracellular d-serine level which modulates the
activity of the N-methyl-d-aspartate receptor and its dysfunction has been linked to several …

Enhancing Electrochemical Biosensor Selectivity with Engineered d-Amino Acid Oxidase Enzymes for d-Serine and d-Alanine Quantification

S Moussa, G Murtas, L Pollegioni… - ACS Applied Bio …, 2021 - ACS Publications
d-Amino acid oxidase (DAAO) enzymes bind a range of d-amino acids with variable affinity.
As such, the design of selective DAAO-based enzymatic biosensors remains a challenge for …

[HTML][HTML] Focus on the role of d-serine and d-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS)

NR Kondori, P Paul, JP Robbins, K Liu… - Frontiers in molecular …, 2018 - frontiersin.org
We have investigated a pathogenic mutation in D-amino acid oxidase (DAO), DAOR199W,
associated with familial Amyotrophic Lateral Sclerosis (ALS) that impairs D-serine …

Structure–function relationships in human D-aspartate oxidase: characterisation of variants corresponding to known single nucleotide polymorphisms

M Katane, R Kanazawa, R Kobayashi, M Oishi… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abstract d-Aspartate oxidase (DDO) is a degradative enzyme that is stereospecific for the
acidic amino acid d-aspartate, an endogenous agonist of the N-methyl-d-aspartate (NMDA) …

[HTML][HTML] A detailed mechanism of the oxidative half-reaction of D-amino acid oxidase: another route for flavin oxidation

DJ Kiss, GG Ferenczy - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
D-Amino acid oxidase (DAAO) is a flavoenzyme whose inhibition is expected to have
therapeutic potential in schizophrenia. DAAO catalyses hydride transfer from the substrate to …

[HTML][HTML] Modulating D-amino acid oxidase (DAAO) substrate specificity through facilitated solvent access

K Subramanian, A Góra, R Spruijt, K Mitusińska… - PLoS …, 2018 - journals.plos.org
D-amino acid oxidase (DAAO) degrades D-amino acids to produce α-ketoacids, hydrogen
peroxide and ammonia. DAAO has often been investigated and engineered for industrial …

Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase

S Khan, S Upadhyay, U Dave, A Kumar… - International Journal of …, 2024 - Elsevier
The D-amino acid oxidase protein modulates neurotransmission by controlling the levels of
D-serine, a co-agonist of N-methyl-D-aspartate receptors. Mutations in the DAO gene have …