Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

Autophagy is an evolutionarily conserved catabolic process that plays an essential role in
maintaining cellular homeostasis by degrading unneeded cell components. When exposed …

Highlights•Nucleolin is overexpressed at the surface cancer cells and tumor
vasculature.•Nucleolin enables dual cellular targeting strategies.•Surface nucleolin as a …

Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many
modulations including rDNA transcription, RNA metabolism, and ribosome assembly …

There is still a need for improving the treatment of breast cancer with doxorubicin (DOX). In
this paper, we functionalized magnetic nanoparticles (MNPs) with DOX and studied the DOX …

Triple negative breast cancer is an aggressive type of cancer with limited therapeutic
options. Aptamer-functionalized liposomes to deliver short interference RNAs (siRNAs) offer …

AS1411 binds nucleolin (NCL) and is the first oligodeoxynucleotide aptamer to reach phase
I and II clinical trials for the treatment of several cancers. However, the mechanisms by which …

Pancreatic cancer remains one of the deadliest human cancers despite current advances in
conventional therapeutics including surgery and adjuvant therapies. Here, we showed that …

The benefits of treating several types of cancers using immunotherapy have recently been
established. The overexpression of nucleolin (NCL) in a number of types of cancer provides …