Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
The persistence of CD4+ T cells carrying latent human immunodeficiency virus-1 (HIV-1)
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
proviruses is the main barrier to a cure. New therapeutics to enhance HIV-1-specific immune …
Human galectin-9 promotes the expansion of HIV reservoirs in vivo in humanized mice
Z Yuan, LB Giron, C Hart, A Gyampoh, J Koshy… - AIDS, 2023 - journals.lww.com
Objective: The human endogenous protein galectin-9 (Gal-9) reactivates latently HIV-
infected cells in vitro and ex vivo, which may allow for immune-mediated clearance of these …
infected cells in vitro and ex vivo, which may allow for immune-mediated clearance of these …
Cross-species transmission and evolution of SIV chimpanzee progenitor viruses toward HIV-1 in humanized mice
K Schmitt, J Curlin, L Remling-Mulder… - Frontiers in …, 2020 - frontiersin.org
The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species
transmission is not well understood. Here we simulated the SIVcpz initial transmission to …
transmission is not well understood. Here we simulated the SIVcpz initial transmission to …
In vivo Infection Dynamics and Human Adaptive Changes of SIVsm-Derived Viral Siblings SIVmac239, SIVB670, and SIVhu in Humanized Mice as a Paralog of HIV …
JZ Curlin, K Schmitt, L Remling-Mulder… - Frontiers in …, 2021 - frontiersin.org
Simian immunodeficiency virus native to sooty mangabeys (SIVsm) is believed to have
given rise to HIV-2 through cross-species transmission and evolution in the human …
given rise to HIV-2 through cross-species transmission and evolution in the human …
SIVcpz cross‐species transmission and viral evolution toward HIV‐1 in a humanized mouse model
J Curlin, K Schmitt, L Remling‐Mulder… - Journal of medical …, 2020 - Wiley Online Library
HIV‐1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the
human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species …
human host. We followed the evolution of SIVcpz in humanized mice to mimic cross‐species …
Ex vivo and in vivo HIV-1 latency reversal by Mukungulu, a protein kinase C-activating African medicinal plant extract
K Richard, Z Yuan, HY Tang, AR Goldman, R Kuthu… - bioRxiv, 2024 - biorxiv.org
Current HIV latency reversing agents (LRAs) have had limited success in clinic, indicating
the need for new strategies that can reactivate and/or eliminate HIV reservoirs. Mukungulu …
the need for new strategies that can reactivate and/or eliminate HIV reservoirs. Mukungulu …
Post-entry restriction factors of SIVcpz
AP Twizerimana, R Scheck, D Häussinger… - Future Virology, 2018 - Taylor & Francis
Pandemic HIV-1, a human lentivirus, is the result of zoonotic transmission of SIV from
chimpanzees (SIVcpz). How SIVcpz established spread in humans after spillover is an …
chimpanzees (SIVcpz). How SIVcpz established spread in humans after spillover is an …
Modeling the Evolution of SIV Progenitor Viruses Ttowards HIV-1 and HIV-2 in a Humanized Mouse Surrogate Model
JZ Curlin - 2020 - search.proquest.com
Abstract Human Immunodeficiency Virus Type 1 (HIV-1) and Type 2 (HIV-2), the causative
agents of Acquired Immunodeficiency Syndrome (AIDS) first emerged in humans over the …
agents of Acquired Immunodeficiency Syndrome (AIDS) first emerged in humans over the …
Efforts in Preventing and Curing HIV/AIDS: A Systematic Review
LASM Exposto… - Interdisciplinary …, 2021 - iss.internationaljournallabs.com
Background: HIV/AIDS disease is a disease that continues to grow and become a global
problem that hit the world. HIV/AIDS is a public health problem that requires serious …
problem that hit the world. HIV/AIDS is a public health problem that requires serious …