Endophytic fungi: from symbiosis to secondary metabolite communications or vice versa?

B Alam, J Lǐ, Q Gě, MA Khan, J Gōng… - Frontiers in Plant …, 2021 - frontiersin.org
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …

A Compressive Review about Taxol®: History and Future Challenges

J Gallego-Jara, G Lozano-Terol, RA Sola-Martínez… - Molecules, 2020 - mdpi.com
Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat
different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to …

Taxanes in cancer treatment: Activity, chemoresistance and its overcoming

L Mosca, A Ilari, F Fazi, YG Assaraf, G Colotti - Drug Resistance Updates, 2021 - Elsevier
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

Y Zhang, L Wiese, H Fang, S Alseekh, LP de Souza… - Molecular Plant, 2023 - cell.com
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …

The Taxus genome provides insights into paclitaxel biosynthesis

X Xiong, J Gou, Q Liao, Y Li, Q Zhou, G Bi, C Li, R Du… - Nature Plants, 2021 - nature.com
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug
paclitaxel, yet no reference genome sequences are available for comprehensively …

Anticancer activity of natural compounds from plant and marine environment

A Lichota, K Gwozdzinski - International journal of molecular sciences, 2018 - mdpi.com
This paper describes the substances of plant and marine origin that have anticancer
properties. The chemical structure of the molecules of these substances, their properties …

Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application

AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …

Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

Y Zhao, F Liang, Y Xie, YT Duan… - Journal of the …, 2023 - ACS Publications
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …

Strategies and lessons learned from total synthesis of taxol

L Min, JC Han, W Zhang, CC Gu, YP Zou… - Chemical …, 2023 - ACS Publications
Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review

AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …