Endophytic fungi: from symbiosis to secondary metabolite communications or vice versa?
B Alam, J Lǐ, Q Gě, MA Khan, J Gōng… - Frontiers in Plant …, 2021 - frontiersin.org
Endophytic fungi (EF) are a group of fascinating host-associated fungal communities that
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …
colonize the intercellular or intracellular spaces of host tissues, providing beneficial effects to …
A Compressive Review about Taxol®: History and Future Challenges
Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat
different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to …
different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to …
Taxanes in cancer treatment: Activity, chemoresistance and its overcoming
Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …
Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis
The diterpenoid paclitaxel (Taxol) is a chemotherapy medication widely used as a first-line
treatment against several types of solid cancers. The supply of paclitaxel from natural …
treatment against several types of solid cancers. The supply of paclitaxel from natural …
The Taxus genome provides insights into paclitaxel biosynthesis
The ancient gymnosperm genus Taxus is the exclusive source of the anticancer drug
paclitaxel, yet no reference genome sequences are available for comprehensively …
paclitaxel, yet no reference genome sequences are available for comprehensively …
Anticancer activity of natural compounds from plant and marine environment
A Lichota, K Gwozdzinski - International journal of molecular sciences, 2018 - mdpi.com
This paper describes the substances of plant and marine origin that have anticancer
properties. The chemical structure of the molecules of these substances, their properties …
properties. The chemical structure of the molecules of these substances, their properties …
Plant secondary metabolites as anticancer agents: successes in clinical trials and therapeutic application
AML Seca, DCGA Pinto - International journal of molecular sciences, 2018 - mdpi.com
Cancer is a multistage process resulting in an uncontrolled and abrupt division of cells and
is one of the leading causes of mortality. The cases reported and the predictions for the near …
is one of the leading causes of mortality. The cases reported and the predictions for the near …
Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme
Taxol is a potent drug used in various cancer treatments. Its complex structure has prompted
extensive research into its biosynthesis. However, certain critical steps, such as the …
extensive research into its biosynthesis. However, certain critical steps, such as the …
Strategies and lessons learned from total synthesis of taxol
L Min, JC Han, W Zhang, CC Gu, YP Zou… - Chemical …, 2023 - ACS Publications
Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …
anticancer drug ever produced and one of the most common prescriptions in the treatment of …
[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review
AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …
therapeutic potential, and nowadays still represent an important pool for the identification of …