Recent advances in the biosynthesis of nucleoside antibiotics
T Shiraishi, T Kuzuyama - The Journal of Antibiotics, 2019 - nature.com
Nucleoside antibiotics are a diverse class of natural products with promising biomedical
activities. These compounds contain a saccharide core and a nucleobase. Despite the large …
activities. These compounds contain a saccharide core and a nucleobase. Despite the large …
Harnessing synthetic biology-based strategies for engineered biosynthesis of nucleoside natural products in actinobacteria
R Gong, L Yu, Y Qin, NPJ Price, X He, Z Deng… - Biotechnology …, 2021 - Elsevier
Antibiotic resistance poses an increasing threat to global health, and it is urgent to reverse
the present trend by accelerating development of new natural product derived drugs …
the present trend by accelerating development of new natural product derived drugs …
Anti-Foc RT4 Activity of a Newly Isolated Streptomyces sp. 5–10 From a Medicinal Plant (Curculigo capitulata)
T Yun, M Zhang, D Zhou, T Jing, X Zang, D Qi… - Frontiers in …, 2021 - frontiersin.org
Fusarium wilt of banana caused by Fusarium oxysporum f. sp. cubense (Foc) is a disastrous
soil-borne fungal disease. Foc tropical race 4 (Foc TR4) can infect almost all banana …
soil-borne fungal disease. Foc tropical race 4 (Foc TR4) can infect almost all banana …
The miharamycins and amipurimycin: their structural revision and the total synthesis of the latter
S Wang, Q Zhang, Y Zhao, J Sun… - Angewandte Chemie …, 2019 - Wiley Online Library
The structural puzzle of amipurimycin, a peptidyl nucleoside antibiotic, is solved by total
synthesis and X‐ray diffraction analysis, with the originally proposed configurations at C3 …
synthesis and X‐ray diffraction analysis, with the originally proposed configurations at C3 …
The amipurimycin and miharamycin biosynthetic gene clusters: unraveling the origins of 2-aminopurinyl peptidyl nucleoside antibiotics
AJ Romo, T Shiraishi, H Ikeuchi, GM Lin… - Journal of the …, 2019 - ACS Publications
Peptidyl nucleoside antibiotics (PNAs) are a diverse class of natural products with promising
biomedical activities. These compounds have tripartite structures composed of a core …
biomedical activities. These compounds have tripartite structures composed of a core …
Characterization of Miharamycin biosynthesis reveals a hybrid NRPS–PKS to synthesize high-carbon sugar from a complex nucleoside
F Wang, WH Zhang, J Zhao, WJ Kang… - Journal of the …, 2020 - ACS Publications
Miharamycins are peptidyl nucleoside antibiotics with a unique branched C9 pyranosyl
amino acid core and a rare 2-aminopurine moiety. Inactivation of 19 genes in the …
amino acid core and a rare 2-aminopurine moiety. Inactivation of 19 genes in the …
Identification and Characterization of Enzymes Catalyzing Early Steps in Miharamycin and Amipurimycin Biosynthesis
WH Zhang, F Wang, YL Wang, S You, HX Pan… - Organic …, 2021 - ACS Publications
The biochemical elucidation of the early biosynthetic pathways of miharamycins and
amipurimycin revealed the roles of several enzymes, which include GMP hydrolase …
amipurimycin revealed the roles of several enzymes, which include GMP hydrolase …
Solving the Structural Puzzles of Amipurimycin and Miharamycins Enabled by Stereodivergent Total Synthesis
B Yu, S Wang - The Chemical Record, 2021 - Wiley Online Library
The efforts toward the synthesis of amipurimycin and miharamycin A/B, two peptidyl
nucleoside antibiotics bearing a unique nine carbon C3‐branched pyranosyl amino acid …
nucleoside antibiotics bearing a unique nine carbon C3‐branched pyranosyl amino acid …