Native chemical ligation (NCL) provides a highly efficient and robust means to
chemoselectively link unprotected peptide and protein segments to generate proteins. The …

The growing interest in proteins, both in fundamental research and in drug discovery, has
fuelled demand for efficient synthetic methods to access these biomolecules. Although solid …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

Highlights•Dha in proteins is easily and flexibly accessible under mild conditions.•Dha
reactivity is used in β, γ-C–S/Se/N/C bond-formation and allows 'zero scar'protein …

Selenocysteine, the selenium‐containing analogue of cysteine, is the twenty‐first
proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Conjugation of polymer to protein has been widely employed in therapeutics, medicine,
biotechnology, and enzymatic catalysis. The synergistic effect benefits both counterparts and …

The importance of modified peptides and proteins for applications in drug discovery, and for
illuminating biological processes at the molecular level, is fueling a demand for efficient …

Rapid and in-depth exploration of the chemical space of high-molecular-weight synthetic
polypeptides via ring-opening polymerization of N-carboxyanhydride allows the discovery of …