Hormonal regulation of mammary gland development and lactation
Lactation is critical to infant short-term and long-term health and protects mothers from
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …
breast cancer, ovarian cancer and type 2 diabetes mellitus. The mammary gland is a …
Impact of risk factors on early cancer evolution
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
[HTML][HTML] limma powers differential expression analyses for RNA-sequencing and microarray studies
Abstract limma is an R/Bioconductor software package that provides an integrated solution
for analysing data from gene expression experiments. It contains rich features for handling …
for analysing data from gene expression experiments. It contains rich features for handling …
[HTML][HTML] Stem cells and the differentiation hierarchy in mammary gland development
NY Fu, E Nolan, GJ Lindeman… - Physiological …, 2020 - journals.physiology.org
The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …
epithelium during puberty and the reproductive cycle. These changes are fueled by …
[HTML][HTML] The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …
female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated …
Adiposity and cancer risk: new mechanistic insights from epidemiology
Excess body adiposity, commonly expressed as body mass index (BMI), is a risk factor for
many common adult cancers. Over the past decade, epidemiological data have shown that …
many common adult cancers. Over the past decade, epidemiological data have shown that …
Mammary gland development: cell fate specification, stem cells and the microenvironment
JL Inman, C Robertson, JD Mott, MJ Bissell - Development, 2015 - journals.biologists.com
The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …
Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses
Variations in sample quality are frequently encountered in small RNA-sequencing
experiments, and pose a major challenge in a differential expression analysis. Removal of …
experiments, and pose a major challenge in a differential expression analysis. Removal of …
[HTML][HTML] Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early …
Abstract The 12th St Gallen International Breast Cancer Conference (2011) Expert Panel
adopted a new approach to the classification of patients for therapeutic purposes based on …
adopted a new approach to the classification of patients for therapeutic purposes based on …