Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …

Targeted protein degradation (TPD) has emerged as a promising approach for drug
development, particularly for undruggable targets. TPD technology has also been …

ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of
linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used …

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as
the primary therapeutic paradigm targeting pathogenic proteins. However, their efficacy …

A repertoire of proteolysis-targeting signals known as degrons is a necessary component of
protein homeostasis in every living cell. In bacteria, degrons can be used in place of …

Polo-like kinase 1 (PLK1) is an essential protein kinase with multiple roles in mitotic
progression. PLK1 consists of a kinase domain (KD) and a phosphopeptide-binding polobox …

Current traditional drugs such as enzyme inhibitors and receptor agonists/antagonists
present inherent limitations due to occupancy-driven pharmacology as the mode of action …

Targeted protein degradation (TPD) holds great promise for biological inquiry and
therapeutic development. However, it still remains elusive to destruct DNA/RNA binding …