Antibacterial drugs are among the most commonly used medications in the world.
Tetracycline is a widely used antibiotic for human and animal therapy due to its broad …

The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …

Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

The tetracycline antibiotic class has acquired new valuable members due to the optimisation
of the chemical structure. The first modern tetracycline introduced into therapy was …

Tetracyclines possess many properties considered ideal for antibiotic drugs, including
activity against Gram-positive and-negative pathogens, proven clinical safety, acceptable …

Antibiotic resistance is mediated through several distinct mechanisms, most of which are
relatively well understood and the clinical importance of which has long been recognized …