Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …

KRAS is the most frequently mutated human oncogene, and KRAS inhibition has been a
longtime goal. Recently, inhibitors were developed that bind KRASG12C-GDP and react …

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic
target for cancer therapy, while the multifaceted roles of SHP2 complicate the drug discovery …

Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase
involved in several cellular processes. In recent years, SHP2 has been the focus of …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …

Protein tyrosine phosphatase SHP2 is a member of PTPs family associated with cancer such
as leukemia, non-small cell lung cancer, breast cancer, and so on. SHP2 is a promising …

Abstract Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded
by PTPN11, regulates cell proliferation, differentiation, apoptosis and survival via releasing …

Both Src homology-2 domain-containing phosphatase 2 (SHP2) and histone deacetylase
(HDAC) are important oncoproteins and potential immunomodulators. In this study, we first …