Cells living in a complex environment must constantly detect, process and appropriately
respond to changing signals. Therefore, all cellular information processing is dynamic in …

A paper by Bond et al. reported that a single-nucleotide polymorphism (SNP) in the intronic
promoter region of the mouse double minute 2 (MDM2) gene (called SNP309) can …

Since the identification of a well-characterized functional polymorphism named SNP309 in
MDM2, abundant studies were published in the last 2 years to evaluate the association …

Association studies in large series of breast cancer patients can be used to identify single-
nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous …

MDM2 SNP309 is a single nucleotide T> G polymorphism present in intron 1 of the MDM2
gene. A variety of case–control studies have been published evaluating the association …

Background The tumor suppressor gene p53 is involved in multiple cellular pathways
including apoptosis, transcriptional control, and cell cycle regulation. In the last decade it …

PURPOSE: Single nucleotide polymorphism (SNP) at position− 309 (T309G) in MDM-2
promoter induces tumor formation in the individuals possessing inherited p53 mutations …

Sporadic breast cancer in women< 40 years is uncommon in Caucasians, in contrast to a
much earlier onset in Chinese Asians. However, the molecular determinants for this earlier …

The MDM2 oncogene is overexpressed in various human cancers. Its expression correlates
with the phenotypes of high-grade, late-stage, and more resistant tumors. The auto …

Introduction A functional polymorphism within MDM2, SNP309 T> G, has been linked to
early onset cancer. This study examined clinical associations of breast cancer with SNP309 …