Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …

Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Lymphatic metastasis is recognized as the leading manner of metastasis in bladder cancer
(BLCa), but hematogenous metastasis accounts for a majority of cancer-associated deaths …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

The paracellular claudin channel of the thick ascending limb (TAL) of Henle is critical for
Ca++ reabsorption in the kidney. Genome‐wide association studies (GWASs) have …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-
selective and water permeable paracellular channels. Its abundance is under fine control by …

Tight junctions are the apical cell‐cell adhesion that regulate paracellular permeability and
are critical for epithelial cell polarity. Molecular architecture of tight junction has been studied …

Vitamin D receptor (VDR) executes most of the biological functions of vitamin D. Beyond this,
VDR is a transcriptional factor regulating the expression levels of many target genes, such …