Mechanotransduction in development

E Farge - Current topics in developmental biology, 2011 - Elsevier
Biochemical patterning and morphogenetic movements coordinate the design of embryonic
development. The molecular processes that pattern and closely control morphogenetic …

Computational models for mechanics of morphogenesis

MA Wyczalkowski, Z Chen, BA Filas… - … defects research part …, 2012 - Wiley Online Library
In the developing embryo, tissues differentiate, deform, and move in an orchestrated manner
to generate various biological shapes driven by the complex interplay between genetic …

Evolutionary conservation of early mesoderm specification by mechanotransduction in Bilateria

T Brunet, A Bouclet, P Ahmadi, D Mitrossilis… - Nature …, 2013 - nature.com
The modulation of developmental biochemical pathways by mechanical cues is an
emerging feature of animal development, but its evolutionary origins have not been …

β-Catenin–dependent mechanotransduction dates back to the common ancestor of Cnidaria and Bilateria

E Pukhlyakova, AJ Aman, K Elsayad… - Proceedings of the …, 2018 - National Acad Sciences
Although the genetic regulation of cellular differentiation processes is well established,
recent studies have revealed the role of mechanotransduction on a variety of biological …

Pattern regulation in a regenerating jellyfish

C Sinigaglia, S Peron, J Eichelbrenner, S Chevalier… - Elife, 2020 - elifesciences.org
Jellyfish, with their tetraradial symmetry, offer a novel paradigm for addressing patterning
mechanisms during regeneration. Here we show that an interplay between mechanical …

Morphogenesis as a macroscopic self-organizing process

LV Beloussov - Biosystems, 2012 - Elsevier
We start from reviewing different epistemological constructions used for explaining
morphogenesis. Among them, we explore the explanatory power of a law-centered …

Physics and the canalization of morphogenesis: a grand challenge in organismal biology

M Von Dassow, LA Davidson - Physical biology, 2011 - iopscience.iop.org
Morphogenesis takes place against a background of organism-to-organism and
environmental variation. Therefore, fundamental questions in the study of morphogenesis …

Mechanotransduction during vertebrate neurulation

SY Sokol - Current topics in developmental biology, 2016 - Elsevier
Vertebrate neural tube formation is a complex morphogenetic process, which involves
hundreds of genes dynamically coordinating various behaviors in different cell populations …

A mechanical perspective on vertebral segmentation

L Truskinovsky, G Vitale, TH Smit - International Journal of Engineering …, 2014 - Elsevier
Segmentation is a characteristic feature of the vertebrate body plan. The prevailing
paradigm explaining its origin is the 'clock and wave-front'model, which assumes that the …

Mechanical stress as a regulator of cytoskeletal contractility and nuclear shape in embryonic epithelia

BA Filas, PV Bayly, LA Taber - Annals of biomedical engineering, 2011 - Springer
The mechano-sensitive responses of the heart and brain were examined in the chick
embryo during Hamburger and Hamilton stages 10–12. During these early stages of …