Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to
support and enable rapid proliferation, continuous growth, and survival in hostile conditions …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately
and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its
prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 …

Pantothenate kinase‐associated neurodegeneration (PKAN) is an inborn error of CoA
metabolism causing dystonia, parkinsonism, and brain iron accumulation. Lack of a good …

Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …

Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …

Background Altered lipid metabolism is closely related to the occurrence and development
of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) is a member …

Cellular senescence is a fundamental biological process that has profound implications in
cancer development and therapeutics, but the underlying mechanisms remain elusive. Here …

Lipids are emerging as key players of senescence. Here, we review the exciting new
findings on the diverse roles of lipids in cellular senescence, most of which are enabled by …