Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

[HTML][HTML] Hyaluronic acid: molecular mechanisms and therapeutic trajectory

RC Gupta, R Lall, A Srivastava, A Sinha - Frontiers in veterinary …, 2019 - frontiersin.org
Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer

AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer

Y Luo, Z Yang, Y Yu, P Zhang - International Journal of Biological …, 2022 - Elsevier
Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

Autologous T cells expressing CD30 chimeric antigen receptors for relapsed or refractory Hodgkin lymphoma: an open-label phase I trial

CM Wang, ZQ Wu, Y Wang, YL Guo, HR Dai… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Relapsed or refractory Hodgkin lymphoma is a challenge for medical
oncologists because of poor overall survival. We aimed to assess the feasibility, safety, and …

One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection

W Gu, Y Yan, C Zhang, C Ding… - ACS applied materials & …, 2016 - ACS Publications
In this work, a bottom-up strategy is developed to synthesize water-soluble molybdenum
disulfide quantum dots (MoS2 QDs) through a simple, one-step hydrothermal method using …

The role of CD44 in disease pathophysiology and targeted treatment

AR Jordan, RR Racine, MJP Hennig… - Frontiers in …, 2015 - frontiersin.org
The cell-surface glycoprotein CD44 is involved in a multitude of important physiological
functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte …

Hyaluronic acid as a modern approach in anticancer therapy-review

M Michalczyk, E Humeniuk, G Adamczuk… - International Journal of …, 2022 - mdpi.com
Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Dissecting the dual nature of hyaluronan in the tumor microenvironment

M Liu, C Tolg, E Turley - Frontiers in immunology, 2019 - frontiersin.org
Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often
opposing functions. The biological activities of this polysaccharide depend on its molecular …

Hyaluronan as a therapeutic target in human diseases

J Liang, D Jiang, PW Noble - Advanced Drug Delivery Reviews, 2016 - Elsevier
Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …