Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure
to hyperglycemia and is a major cause of blindness worldwide. Although clinical …

Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

Diabetes mellitus (DM) is a systemic metabolic disease that affects 463 million adults
worldwide and is a leading cause of cardiovascular disease, blindness, nephropathy …

Context Diabetic retinopathy (DR) is a specific microvascular complication in patients with
diabetes and the leading cause of blindness. Recent advances in omics, especially …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …

Rapid repair of plasma membrane wounds is critical for cellular survival. Muscle fibers are
particularly susceptible to injury, and defective sarcolemma resealing causes muscular …

In patients with diabetes mellitus, the ability of ischemic tissue to synchronize the molecular
and cellular events leading to restoration of tissue perfusion in response to the …

The retinal pigment epithelium (RPE) plays an important role in the development of diabetic
retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the …

The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and
have the highest density of mitochondria of any cell in the body. Both physiological and …