Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile
C Miranda-Vera, ÁP Hernández, P García-García… - Pharmaceutics, 2023 - mdpi.com
Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …
Podophyllic Aldehyde, a Podophyllotoxin Derivate, Elicits Different Cell Cycle Profiles Depending on the Tumor Cell Line: A Systematic Proteomic Analysis
ÁP Hernández, L Chaparro-González… - International Journal of …, 2024 - mdpi.com
When new antitumor therapy drugs are discovered, it is essential to address new target
molecules from the point of view of chemical structure and to carry out efficient and …
molecules from the point of view of chemical structure and to carry out efficient and …
Cytotoxic Cyclolignans Obtained by the Enlargement of the Cyclolignan Skeleton of Podophyllic Aldehyde, a Selective Podophyllotoxin-Derived Cyclolignan
PA García, ÁP Hernández, MA Gómez-Zurita… - Molecules, 2024 - mdpi.com
Podophyllotoxin, a cyclolignan natural product, has been the object of extensive
chemomodulation to obtain better chemotherapeutic agents. Among the obtained …
chemomodulation to obtain better chemotherapeutic agents. Among the obtained …