Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Angiotensin II revisited: new roles in inflammation, immunology and aging
That the renin–angiotensin system (RAS) is involved in regulation of blood pressure,
vasoconstriction, sodium intake and potassium excretion is well established. Studies in the …
vasoconstriction, sodium intake and potassium excretion is well established. Studies in the …
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Diabetic nephropathy (DN) is among the most lethal complications that occur in type 1 and
type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with …
type 2 diabetics. Podocyte dysfunction is postulated to be a critical event associated with …
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Q Zhu, PE Scherer - Nature Reviews Nephrology, 2018 - nature.com
Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …
The transition from the lean to the obese state is characterized by fundamental cellular …
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
Novel therapeutics for the treatment of hypertension and its associated complications: peptide-and nonpeptide-based strategies
The renin-angiotensin-aldosterone system (RAAS) is responsible for maintaining blood
pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential …
pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential …
Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice
LP Kil, MJW De Bruijn… - Blood, The Journal …, 2012 - ashpublications.org
On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of
the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up …
the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up …
[HTML][HTML] AT2 receptors in cardiovascular and renal diseases
E Kaschina, P Namsolleck, T Unger - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
Angiotensin II type 2 receptor: a target for protection against hypertension, metabolic dysfunction, and organ remodeling
The renin-angiotensin system is of vital significance not only in the maintenance of blood
pressure but also because of its role in the pathophysiology of different organ systems in the …
pressure but also because of its role in the pathophysiology of different organ systems in the …