Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of
reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and …

Periodontitis is a common inflammatory disease, which is initiated by bacterial infection and
subsequently progressed by aberrant host response. It can result in the destruction of teeth …

Critical-sized bone defect repair in patients with diabetes mellitus remains a challenge in
clinical treatment because of dysfunction of macrophage polarization and the inflammatory …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

Oxidative stress has been implicated in the pathogenesis of numerous diseases. However,
large interventional studies with antioxidants failed to show benefits in the prevention or …

Periodontitis is a periodontal inflammatory condition that results from disrupted periodontal
host–microbe homeostasis, manifested by the destruction of tooth-supporting structures …

Objectives: To qualitatively and quantitatively review the use of melatonin as a
topical/systemic formulation for the management of periodontitis. Materials and methods …

Background: Periodontitis is a chronic disease with a complex etiology that includes
bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin …