Single-cell dissection of the human brain vasculature
Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …
and in understanding neurodegeneration and drug delivery to the central nervous system …
The potential of gene editing for Huntington's disease
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide repeat expansion in the huntingtin gene resulting in long stretches of …
a trinucleotide repeat expansion in the huntingtin gene resulting in long stretches of …
From recognition to remedy: The significance of biomarkers in neurodegenerative disease pathology
C Toader, N Dobrin, FM Brehar, C Popa… - International journal of …, 2023 - mdpi.com
With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …
An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington's disease models
KH Morelli, Q Wu, ML Gosztyla, H Liu, M Yao… - Nature …, 2023 - nature.com
Huntington's disease (HD) is a fatal, dominantly inherited neurodegenerative disorder
caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the …
caused by CAG trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Since the …
[HTML][HTML] Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins
Blood-brain barrier (BBB) plays a critical role in protecting the brain from toxins and
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
[HTML][HTML] Allele-specific silencing of the gain-of-function mutation in Huntington's disease using CRISPR/Cas9
Dominant gain-of-function mechanisms in Huntington's disease (HD) suggest that selective
silencing of mutant HTT produces robust therapeutic benefits. Here, capitalizing on exonic …
silencing of mutant HTT produces robust therapeutic benefits. Here, capitalizing on exonic …
Multiscale imaging informs translational mouse modeling of neurological disease
Multiscale neurophysiology reveals that simple motor actions are associated with changes
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …
in neuronal firing in virtually every brain region studied. Accordingly, the assessment of focal …
Huntington's disease: complex pathogenesis and therapeutic strategies
H Tong, T Yang, S Xu, X Li, L Liu, G Zhou… - International Journal of …, 2024 - mdpi.com
Huntington's disease (HD) arises from the abnormal expansion of CAG repeats in the
huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) …
huntingtin gene (HTT), resulting in the production of the mutant huntingtin protein (mHTT) …
Water-reaching platform for longitudinal assessment of cortical activity and fine motor coordination defects in a Huntington disease mouse model
Huntington disease (HD), caused by dominantly inherited expansions of a CAG repeat
results in characteristic motor dysfunction. Although gross motor defects have been …
results in characteristic motor dysfunction. Although gross motor defects have been …
PAM-altering SNP-based allele-specific CRISPR-Cas9 therapeutic strategies for Huntington's disease
Huntington's disease (HD) is caused by an expanded CAG repeat in huntingtin (HTT). Since
HD is dominant and loss of HTT leads to neurological abnormalities, safe therapeutic …
HD is dominant and loss of HTT leads to neurological abnormalities, safe therapeutic …