Impact of oxidative stress on exercising skeletal muscle

P Steinbacher, P Eckl - Biomolecules, 2015 - mdpi.com
It is well established that muscle contractions during exercise lead to elevated levels of
reactive oxygen species (ROS) in skeletal muscle. These highly reactive molecules have …

Chemical methods for mapping cysteine oxidation

LJ Alcock, MV Perkins, JM Chalker - Chemical Society Reviews, 2018 - pubs.rsc.org
Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …

Activation of SIRT3 by the NAD+ precursor nicotinamide riboside protects from noise-induced hearing loss

KD Brown, S Maqsood, JY Huang, Y Pan, W Harkcom… - Cell metabolism, 2014 - cell.com
Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia
neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD+) …

Molecular mechanisms of quinone cytotoxicity

PJ O'brien - Chemico-biological interactions, 1991 - Elsevier
Quinones are probably found in all respiring animal and plant cells. They are widely used as
anticancer, antibacterial or antimalarial drugs and as fungicides. Toxicity can arise as a …

Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis

PH Shih, CT Yeh, GC Yen - Journal of agricultural and food …, 2007 - ACS Publications
Reactive oxygen species (ROS)-induced cell damage is inevitable and severe and is
involved in numerous diseases, including cancer. Reducing oxidative stress is one of the …

Redox and addition chemistry of quinoid compounds and its biological implications

A Brunmark, E Cadenas - Free Radical Biology and Medicine, 1989 - Elsevier
The overall biological activity of quinones is a function of the physico-chemical properties of
these compounds, which manifest themselves in a critical bimolecular reaction with …

Free radical formation by antitumor quinones

G Powis - Free radical biology and medicine, 1989 - Elsevier
Quinones are among the most frequently used drugs to treat human cancer. All of the
antitumor quinones can undergo reversible enzymatic reduction and oxidation, and form …

Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats

CL Hsu, GC Yen - British Journal of Nutrition, 2007 - cambridge.org
Gallic acid (GA) is a naturally abundant plant phenolic compound in the human diet and is
known to reduce the risk of disease. In this study, the anti-obesity effect of GA in an animal …

Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's …

PH Shih, YC Chan, JW Liao, MF Wang… - The Journal of nutritional …, 2010 - Elsevier
In the present study, we evaluated the beneficial effect of mulberry extracts (ME), which are
rich in phenolics and anthocyanins, on the induction of antioxidant enzymes and on the …

Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis

CA Chrestensen, DW Starke, JJ Mieyal - Journal of Biological Chemistry, 2000 - ASBMB
Oxidative stress broadly impacts cells, initiating regulatory pathways as well as apoptosis
and necrosis. A key molecular event is protein S-glutathionylation, and thioltransferase …