The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

L Kma, TJ Baruah - Biotechnology and applied biochemistry, 2022 - Wiley Online Library
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells

P Biswas, D Dey, PK Biswas, TI Rahaman… - International journal of …, 2022 - mdpi.com
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

Molecular mechanisms of anticancer effect of rutin

A Imani, N Maleki, S Bohlouli… - Phytotherapy …, 2021 - Wiley Online Library
Because of the extensive biological functions of natural substances such as bioflavonoids,
and their high safety and low costs, they could have high priority application in the health …

Free radicals as a double-edged sword: The cancer preventive and therapeutic roles of curcumin

N Gupta, K Verma, S Nalla, A Kulshreshtha, R Lall… - Molecules, 2020 - mdpi.com
Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen
species (RNS), are generated in the body by various endogenous and exogenous systems …

Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment

Y Yang, H Wu, B Liu, Z Liu - Advanced Drug Delivery Reviews, 2021 - Elsevier
Dynamic inorganic nanoassemblies (DINAs) have emerged as smart nanomedicine
platforms with promising potential for bioimaging and targeted drug delivery. In this review …

Impact of ROS generated by chemical, physical, and plasma techniques on cancer attenuation

S Mitra, LN Nguyen, M Akter, G Park, EH Choi… - Cancers, 2019 - mdpi.com
For the last few decades, while significant improvements have been achieved in cancer
therapy, this family of diseases is still considered one of the deadliest threats to human …

Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future …

R Sahadevan, S Singh, A Binoy… - Critical Reviews in Food …, 2023 - Taylor & Francis
Natural products have been a bedrock for drug discovery for decades.(−)-Epigallocatechin-3-
gallate (EGCG) is one of the widely studied natural polyphenolic compounds derived from …

Anticancer effect of pomegranate peel polyphenols against cervical cancer

SL Teniente, AC Flores-Gallegos… - Antioxidants, 2023 - mdpi.com
Polyphenols are a broad group of bioactive phytochemicals with powerful antioxidant, anti-
inflammatory, immunomodulatory, and antiviral activities. Numerous studies have …

Targeting of the tumor microenvironment by curcumin

X Fu, Y He, M Li, Z Huang, M Najafi - Biofactors, 2021 - Wiley Online Library
The tumor microenvironment (TME) is made up of several cells and molecules that affect the
survival of cancer cells. Indeed, certain (immunosuppressive) cells which promote tumors …

Reactive oxygen nano-generators for cancer therapy

D Kalyane, D Choudhary, S Polaka, H Goykar… - Progress in Materials …, 2022 - Elsevier
Reactive oxygen species (ROS) play a vital role in the biological process. Interestingly,
based on the concentration of the ROS level, they can be beneficial or detrimental to tumor …