In striated muscles, shortening comes about by the sliding movement of thick filaments,
composed mostly of myosin, relative to thin filaments, composed mostly of actin. This is …

When the sliding filament hypothesis was proposed in 1953–1954, existing evidence
showed that (1) contributions to tension were given by active sites uniformly distributed …

1 The effect of added inorganic phosphate (Pi, range 3–25 mm) on active tension was
examined at a range of temperatures (5–30° C) in chemically skinned (0.5% Brij) rabbit …

The effect of temperature on elementary steps of the cross-bridge cycle was investigated
with sinusoidal analysis technique in skinned rabbit psoas fibers. We studied the effect of …

Generation of force and shortening in striated muscle is due to the cyclic interactions of the
globular portion (the head) of the myosin molecule, extending from the thick filament, with …

Muscle contraction is due to myosin motors that transiently attach with their globular head to
an actin filament and generate force. After a sudden reduction of the load below the …

We have developed temperature-pulse microscopy in which the temperature of a
microscopic sample is raised reversibly in a square-wave fashion with rise and fall times of …

Fatigue of skeletal muscle involves many systems beginning with the central nervous system
and ending with the contractile machinery. This review concentrates on those factors that …

Observations made in temperature studies on mammalian muscle during force
development, shortening, and lengthening, are re-examined. The isometric force in active …

Myosin produces force in a cyclic interaction, which involves alternate tight binding to actin
and to ATP. We have investigated the energetics associated with force production by …