Classic and exertional heatstroke

A Bouchama, B Abuyassin, C Lehe, O Laitano… - Nature Reviews …, 2022 - nature.com
In the past two decades, record-breaking heatwaves have caused an increasing number of
heat-related deaths, including heatstroke, globally. Heatstroke is a heat illness characterized …

[HTML][HTML] Exertional heat stroke: pathophysiology and risk factors

CK Garcia, LI Renteria, G Leite-Santos, LR Leon… - BMJ …, 2022 - ncbi.nlm.nih.gov
Exertional heat stroke, the third leading cause of mortality in athletes during physical activity,
is the most severe manifestation of exertional heat illnesses. Exertional heat stroke is …

[HTML][HTML] Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota

Y Liu, L Xu, Z Yang, D Wang, T Li, F Yang, Z Li… - Biomedicine & …, 2023 - Elsevier
Sepsis is described as an immune response disorder of the host to infection in which
microorganisms play a non-negligible role. Most survivors of sepsis experience ICU …

The role of skeletal muscles in exertional heat stroke pathophysiology

O Laitano, K Oki, LR Leon - International journal of sports …, 2021 - thieme-connect.com
The active participation of skeletal muscles is a unique characteristic of exertional heat
stroke. Nevertheless, the only well-documented link between skeletal muscle activities and …

Skin transcriptomic analysis reveals candidate genes and pathways associated with thermotolerance in hair sheep

MH de Andrade Pantoja, MD Poleti… - International Journal of …, 2024 - Springer
The skin plays an important role in thermoregulation. Identification of genes on the skin that
contribute to increased heat tolerance can be used to select animals with the best …

Modulated electro-hyperthermia induces a prominent local stress response and growth inhibition in mouse breast cancer isografts

CA Schvarcz, L Danics, T Krenács, P Viana, R Béres… - Cancers, 2021 - mdpi.com
Simple Summary Here we investigated the most aggressive type of breast cancer (triple
negative breast cancer (TNBC)) for which no effective therapies exist. Modulated electro …

A preclinical model of exertional heat stroke in mice

MA King, JM Alzahrani, TL Clanton… - JoVE (Journal of Visualized …, 2021 - jove.com
Heat stroke is the most severe manifestation of heat-related illnesses. Classic heat stroke
(CHS), also known as passive heat stroke, occurs at rest, whereas exertional heat stroke …

Sepsis-induced myopathy and gut microbiome dysbiosis: mechanistic links and therapeutic targets

RT Mankowski, O Laitano, D Darden, L Kelly, J Munley… - Shock, 2022 - journals.lww.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection. The skeletal muscle system is among the host organ systems …

Impact of successive exertional heat injuries on thermoregulatory and systemic inflammatory responses in mice

AR Caldwell, K Oki, SM Ward… - Journal of Applied …, 2021 - journals.physiology.org
The purpose of the study was to determine if repeated exertional heat injuries (EHIs) worsen
the inflammatory response. We assessed the impact of a single EHI bout (EHI0) or two …

Comparison of Transcriptomic Changes in Survivors of Exertional Heat Illness with Malignant Hyperthermia Susceptible Patients

L Chang, L Gardner, C House, C Daly… - International Journal of …, 2023 - mdpi.com
Exertional heat illness (EHI) is an occupational health hazard for athletes and military
personnel–characterised by the inability to thermoregulate during exercise. The ability to …