The heat shock response: life on the verge of death
K Richter, M Haslbeck, J Buchner - Molecular cell, 2010 - cell.com
Organisms must survive a variety of stressful conditions, including sudden temperature
increases that damage important cellular structures and interfere with essential functions. In …
increases that damage important cellular structures and interfere with essential functions. In …
Molecular chaperone functions in protein folding and proteostasis
The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
CCT2 is an aggrephagy receptor for clearance of solid protein aggregates
X Ma, C Lu, Y Chen, S Li, N Ma, X Tao, Y Li, J Wang… - Cell, 2022 - cell.com
Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively
degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive …
degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive …
[HTML][HTML] A human interactome in three quantitative dimensions organized by stoichiometries and abundances
The organization of a cell emerges from the interactions in protein networks. The
interactome is critically dependent on the strengths of interactions and the cellular …
interactome is critically dependent on the strengths of interactions and the cellular …
[HTML][HTML] Widespread macromolecular interaction perturbations in human genetic disorders
How disease-associated mutations impair protein activities in the context of biological
networks remains mostly undetermined. Although a few renowned alleles are well …
networks remains mostly undetermined. Although a few renowned alleles are well …
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Abstract Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that
facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched …
facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched …
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
Chaperones are abundant cellular proteins that promote the folding and function of their
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
Functional modules of the proteostasis network
Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis)
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …
Converging concepts of protein folding in vitro and in vivo
FU Hartl, M Hayer-Hartl - Nature structural & molecular biology, 2009 - nature.com
Most proteins must fold into precise three-dimensional conformations to fulfill their biological
functions. Here we review recent concepts emerging from studies of protein folding in vitro …
functions. Here we review recent concepts emerging from studies of protein folding in vitro …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …