Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered
in bone marrow, are multipotent cells capable of differentiating into mature cells of several …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue
homeostasis, and their dysregulation contributes to human cancer. Here, we discover …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

The repressive Hippo pathway has a profound tumour suppressive role in cancer by
restraining the growth-promoting function of the transcriptional coactivator, YAP. We …

Highlights•YAP/TAZ are activated in a broad number of solid tumors.•YAP/TAZ instrumental
for tumor initiation, growth, metastasis and chemoresistance.•Several inputs control …

The Wnt signalling pathway is one of the central signalling pathways in bone development,
homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands …