Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …

Introduction: To overcome potential problems with solid-state APIs, such as polymorphism,
solubility and bioavailability, pure liquid salt (ionic liquid) forms of active pharmaceutical …

Differences in the predicted aqueous pKa values (ΔpKa) have been calculated for 6465
crystalline complexes containing ionised and non-ionised acid–base pairs in the Cambridge …

The Orange Book database published by the US Drug and Food Administration (FDA) was
analyzed for the frequency of occurrence of different counterions used for the formation of …

The ΔpKa rule is commonly applied by chemists and crystal engineers as a guideline for the
rational design of molecular salts and co-crystals. For multi-component crystals containing …

Ionic liquids (ILs) are organic salts with a melting point below 100° C. Active pharmaceutical
ingredients (APIs) are transformed into ILs by combining them with typically large yet …

Crystal engineering provides a rational approach to solving formulation, processing and
product performance problems. This review discusses how the concept of crystal …

The synthesis of self-assembled metallosupramolecular architectures has been of steadily
growing interest in recent years due to their diverse applications. Appending additional …

A 1: 1 cocrystal involving an analgesic drug, ethenzamide (EA), and 3, 5-dinitrobenzoic acid
exists in two polymorphs and forms a series of solvates. All the crystalline materials have …

Caffeine, a pharmaceutical model compound, generally forms cocrystals with carboxylic
acids that involve an O− H··· N hydrogen bond between the carboxylic acid group of the acid …