Allostery is a universal, biological phenomenon in which orthosteric sites are fine‐tuned by
topologically distal allosteric sites triggered by perturbations, such as ligand binding, residue …

At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …

Allostery in proteins influences various biological processes such as regulation of gene
transcription and activities of enzymes and cell signaling. Computational approaches for …

Response regulators function as the output components of two-component systems, which
couple the sensing of environmental stimuli to adaptive responses. Response regulators …

Highlights•The intrinsic dynamics, encoded in proteins' sequences and structures, are
utilized by stimuli to trigger allosteric and functional actions.•The modes of allosteric actions …

Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Highlights•Allosteric drugs have become an indispensable tool in precision medicine.•Major
targets for allosteric drugs: diversity structures and functions.•Allosteric effects of mutations …

We introduce a numerical scheme to evolve functional elastic materials that can accomplish
a specified mechanical task. In this scheme, the number of solutions, their spatial …

Allostery is considered important in regulating protein's activity. Drug development depends
on the understanding of allosteric mechanisms, especially the identification of allosteric …

Structural insights have been revealed from X-ray co-complexes of a range of G protein-
coupled receptors (GPCRs) and their allosteric ligands. The understanding of how small …