Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

While the opioid epidemic has garnered significant attention, the use of methamphetamines
is growing worldwide independent of wealth or region. Following overdose and accidents …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Nicotine stimulates the dopamine (DA) system, which is essential for its rewarding effect.
Nicotine is also aversive at high doses; yet, our knowledge about nicotine's dose-dependent …

Methamphetamine (METH) is an illicit psychostimulant that is subject to abuse worldwide.
While the modulatory effects of METH on dopamine neurotransmission and its neurotoxicity …

Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely
abused drugs worldwide. The continuous use of METH eventually leads to drug addiction …

Lasker's award-winning drug propofol is widely used in general anesthesia. The
recreational use of propofol is reported to produce a well-rested feeling and euphoric state; …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Our understanding of the role of innate and adaptive immune cell function in brain health
and how it goes awry during aging and neurodegenerative diseases is still in its infancy …

Depression and cognitive disorders are diseases with complex and not-fully understood
etiology. Unfortunately, the COVID-19 pandemic dramatically increased the prevalence of …