Inheritance of mild mutations within the β-globin gene and coinheritance of α-thalassemia (α-
thal) are known as two important genetic modifiers in β-thalassemia (β-thal) intermedia (β …

Background: HYDROXYUREA (HU) is a well known chemotherapeutic agent that has been
used largely for various myeloproliferative diseases over the past 20 years. In b …

Beta-thalassemia, by its high frequency and heterogenecity, constitues a real problem of
health in Iran. Aboute 13 beta globin mutations encompass 70-90% of mutations spectrum in …

Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that leads to axon
demyelination and white matter plaque formation. The aim of the present study is to inspect …

BACKGROUND: Thalassemia is one of the most common genetic health problems in the
world. More than 200 different mutations have been identified in the beta-globin gene and …

Polymorphisms in the CD40 ligand gene (CD40LG) are associated with various
immunological disorders such as tumors, autoimmune and infectious diseases. The aim of …

A nanodiagnostic genotyping method was presented for point mutation detection directly in
human genomic DNA based on ligase reaction coupled with quantum dots and magnetic …

Thalassemias are the world's most widespread genetic disorder known in m, m.
22According to a WHO report, 25 thalassemia carriers are estimated to exceed 100 million …

Abstract Beta-thalassemia (β-thalassemia) is a globally genetic diseases, and is most
prevalent in the Middle East, particularly in Iran. Carrier detection and prenatal diagnosis are …

Minor deviations in the script of human life (the genetic code) are known to have major
consequences on human health and well-being. Even substitution of a single nucleotide …