Stem cells therapy for spinal cord injury: an overview of clinical trials

S Silvestro, P Bramanti, O Trubiani… - International Journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or
permanent sensory and/or motor deficits. The pharmacological approach still in use for the …

Cell transplantation for spinal cord injury: a systematic review

J Li, G Lepski - BioMed research international, 2013 - Wiley Online Library
Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been
extensively studied by researchers in recent years. A number of different kinds of stem cells …

Clinical observation of umbilical cord mesenchymal stem cell transplantation in treatment for sequelae of thoracolumbar spinal cord injury

H Cheng, X Liu, R Hua, G Dai, X Wang, J Gao… - Journal of Translational …, 2014 - Springer
Background Umbilical cord mesenchymal stem cells (UCMSCs) have a considerable
advantage and potential in treating for central nervous system diseases and have become a …

Clinical trial of human fetal brain‐derived neural stem/progenitor cell transplantation in patients with traumatic cervical spinal cord injury

JC Shin, KN Kim, J Yoo, IS Kim, S Yun, H Lee… - Neural …, 2015 - Wiley Online Library
In a phase I/IIa open‐label and nonrandomized controlled clinical trial, we sought to assess
the safety and neurological effects of human neural stem/progenitor cells (hNSPCs) …

[HTML][HTML] Cellular treatments for spinal cord injury: the time is right for clinical trials

MG Fehlings, R Vawda - Neurotherapeutics, 2011 - Elsevier
More than 1 million people in the United States live with a spinal cord injury (SCI). Despite
medical advances, many patients with SCIs still experience substantial neurological …

Subventricular zone-derived extracellular vesicles promote functional recovery in rat model of spinal cord injury by inhibition of NLRP3 inflammasome complex …

I Mohammed, S Ijaz, T Mokhtari, M Gholaminejhad… - Metabolic brain …, 2020 - Springer
Spinal cord injury (SCI) is the destruction of spinal cord motor and sensory resulted from an
attack on the spinal cord, which can cause significant physiological damage. The …

Mesenchymal cells in the treatment of spinal cord injury: current & future perspectives

R Vawda, MG Fehlings - Current stem cell research & therapy, 2013 - ingentaconnect.com
Nearly 1.5 million people in the US live with a spinal cord injury (SCI). The cost to the
healthcare system is estimated at over $10 billion annually likely because over 65% of SCIs …

Platelet-rich plasma and the elimination of neuropathic pain

DP Kuffler - Molecular neurobiology, 2013 - Springer
Peripheral neuropathic pain typically results from trauma-induced nociceptive neuron
hyperexcitability and their spontaneous ectopic activity. This pain persists until the trauma …

Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review

B Tian, J Liu, S Guo, A Li, JB Wan - International Journal of Biological …, 2023 - Elsevier
The role of regenerative medicine in clinical therapies is becoming increasingly vital. Under
specific conditions, mesenchymal stem cells (MSCs) are capable of differentiating into …

Sustained dual drug delivery of anti-inhibitory molecules for treatment of spinal cord injury

TS Wilems, SE Sakiyama-Elbert - Journal of Controlled Release, 2015 - Elsevier
Myelin-associated inhibitors (MAIs) and chondroitin sulfate proteoglycans (CSPGs) are
major contributors to axon growth inhibition following spinal cord injury and limit functional …