Synthetic oligonucleotide analogs have greatly aided our understanding of several
biochemical processes. Efficient solid-phase and enzyme-assisted synthetic methods and …

RNA engineering for nanotechnology and medical applications is an exciting emerging
research field. RNA has intrinsically defined features on the nanometre scale and is a …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

Abstract SINGLE-STRANDED DNA can fold into well-defined sequence-dependent tertiary
structures that specifically bind a variety of target molecules1–10, raising the possibility that …

A systematic study of selectively modified, 36-mer hammerhead ribozymes has resulted in
the identification of a generic, catalytically active and nuclease stable ribozyme motif …

Biological macromolecules including DNA, RNA, and proteins, have intrinsic features that
make them potential building blocks for the bottom-up fabrication of nanodevices. RNA is …

The hammerhead ribozyme is a small RNA motif that self cleaves at a specific
phosphodiester bond to produce 2′, 3′ cyclic phosphate and 5′ hydroxyl termini …

Using a computer program designed to search for RNA structural motifs in sequence
databases, we have found a hammerhead ribozyme domain encoded in the Smα repetitive …

For the understanding of the catalytic function of the RNA hammerhead ribozyme, a three-
dimensional model is essential but neither a crystal nor a solution structure has been …