Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

There is a growing body of evidence demonstrating that stress decreases the expression of
brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that …

Electroconvulsive therapy (ECT) is a time tested treatment modality for the management of
various psychiatric disorders. There have been a lot of modifications in the techniques of …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

To better understand the molecular mechanisms of depression and antidepressant action,
we administered chronic social defeat stress followed by chronic imipramine (a tricyclic …

Synaptic activity initiates biochemical processes that have various outcomes, including the
formation of memories, increases in neuronal survival and the development of chronic pain …

Major depressive disorder (MDD) is a heterogeneous illness for which there are currently no
effective methods to objectively assess severity, endophenotypes, or response to treatment …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

The transcription factor CREB is best known for its involvement in learning and memory.
However, emerging evidence suggests that CREB activity has very different roles …