Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis

Y Li, J Wang, L Li, W Song, M Li, X Hua… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …

Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Biosynthesis and biotechnological production of the anti-obesity agent celastrol

Y Zhao, NL Hansen, YT Duan, M Prasad… - Nature Chemistry, 2023 - nature.com
Obesity is a major health risk still lacking effective pharmacological treatment. A potent anti-
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …

[HTML][HTML] Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

NL Hansen, L Kjaerulff, QK Heck, V Forman… - Nature …, 2022 - nature.com
The diterpenoid triepoxides triptolide and triptonide from Tripterygium wilfordii (thunder god
wine) exhibit unique bioactivities with potential uses in disease treatment and as a non …

[HTML][HTML] Engineering yeast for the production of plant terpenoids using synthetic biology approaches

JA Bureau, ME Oliva, Y Dong, C Ignea - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …

Celastrol in metabolic diseases: Progress and application prospects

S Xu, Y Feng, W He, W Xu, W Xu, H Yang, X Li - Pharmacological research, 2021 - Elsevier
Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

[HTML][HTML] Plant cytochrome P450 plasticity and evolution

CC Hansen, DR Nelson, BL Møller, D Werck-Reichhart - Molecular Plant, 2021 - cell.com
The superfamily of cytochrome P450 (CYP) enzymes plays key roles in plant evolution and
metabolic diversification. This review provides a status on the CYP landscape within green …

[HTML][HTML] A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

K Miettinen, N Leelahakorn, A Almeida, Y Zhao… - Nature …, 2022 - nature.com
Eukaryotic cells use G-protein coupled receptors to sense diverse signals, ranging from
chemical compounds to light. Here, we exploit the remarkable sensing capacity of G-protein …

The tomato cytochrome P450 CYP712G1 catalyses the double oxidation of orobanchol en route to the rhizosphere signalling strigolactone, solanacol

Y Wang, J Durairaj, HG Suárez Duran… - New …, 2022 - Wiley Online Library
Strigolactones (SLs) are rhizosphere signalling molecules and phytohormones. The
biosynthetic pathway of SLs in tomato has been partially elucidated, but the structural …

Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol

Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …