Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis
Y Li, J Wang, L Li, W Song, M Li, X Hua… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …
Recent advances in triterpenoid pathway elucidation and engineering
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …
Biosynthesis and biotechnological production of the anti-obesity agent celastrol
Y Zhao, NL Hansen, YT Duan, M Prasad… - Nature Chemistry, 2023 - nature.com
Obesity is a major health risk still lacking effective pharmacological treatment. A potent anti-
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …
[HTML][HTML] Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide
NL Hansen, L Kjaerulff, QK Heck, V Forman… - Nature …, 2022 - nature.com
The diterpenoid triepoxides triptolide and triptonide from Tripterygium wilfordii (thunder god
wine) exhibit unique bioactivities with potential uses in disease treatment and as a non …
wine) exhibit unique bioactivities with potential uses in disease treatment and as a non …
[HTML][HTML] Engineering yeast for the production of plant terpenoids using synthetic biology approaches
Covering: 2011–2022 The low amounts of terpenoids produced in plants and the difficulty in
synthesizing these complex structures have stimulated the production of terpenoid …
synthesizing these complex structures have stimulated the production of terpenoid …
Celastrol in metabolic diseases: Progress and application prospects
S Xu, Y Feng, W He, W Xu, W Xu, H Yang, X Li - Pharmacological research, 2021 - Elsevier
Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …
essential to develop effective drugs or new treatments for metabolic diseases. As an active …
[HTML][HTML] Plant cytochrome P450 plasticity and evolution
The superfamily of cytochrome P450 (CYP) enzymes plays key roles in plant evolution and
metabolic diversification. This review provides a status on the CYP landscape within green …
metabolic diversification. This review provides a status on the CYP landscape within green …
[HTML][HTML] A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Eukaryotic cells use G-protein coupled receptors to sense diverse signals, ranging from
chemical compounds to light. Here, we exploit the remarkable sensing capacity of G-protein …
chemical compounds to light. Here, we exploit the remarkable sensing capacity of G-protein …
The tomato cytochrome P450 CYP712G1 catalyses the double oxidation of orobanchol en route to the rhizosphere signalling strigolactone, solanacol
Y Wang, J Durairaj, HG Suárez Duran… - New …, 2022 - Wiley Online Library
Strigolactones (SLs) are rhizosphere signalling molecules and phytohormones. The
biosynthetic pathway of SLs in tomato has been partially elucidated, but the structural …
biosynthetic pathway of SLs in tomato has been partially elucidated, but the structural …
Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol
Y Lu, Y Liu, J Zhou, D Li, W Gao - Medicinal research reviews, 2021 - Wiley Online Library
Celastrol, a quinone‐methide triterpenoid, was extracted from Tripterygium wilfordii Hook. F.
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …
in 1936 for the first time. Almost 70 years later, it is considered one of the molecules most …