The goal of treatment for early stage rectal cancer is to optimize oncologic control while
minimizing the long-term impact of treatment on quality of life. The standard of care treatment …

Background A uniform definition of a clinical near-complete response (near-CR) after
neoadjuvant (chemo) radiotherapy for rectal cancer is lacking. A clear definition is necessary …

Importance Treatment of rectal cancer is shifting toward organ preservation aiming to reduce
surgery-related morbidity. Short-term outcomes of organ-preserving strategies are …

BACKGROUND: Organ-preserving strategies have been considered for patients with distal
rectal cancer and complete or near-complete response to neoadjuvant chemoradiation to …

Background Transanal endoscopic microsurgery (TEM) has been considered an alternative
for selected patients with rectal cancer following neoadjuvant chemoradiation (CRT) …

Abstract Treatment of rectal cancer patients has been subjected to change over the past
thirty years. Total mesorectal excision is considered the cornerstone of rectal cancer …

Background Deferral of conventional surgery for rectal cancer after neo-adjuvant chemo-
radiotherapy is gaining increasing interest, particularly for patients who are too frail to …

Tumor response to neoadjuvant chemoradiation (nCRT) with tumor downsizing and
downstaging has significantly impacted the number of patients considered to be appropriate …

In recent years, organ preservation has been considered a feasible alternative to total
mesorectal excision for patients with locally advanced rectal cancer with a clinical complete …

Background There are no guidelines on clinical target volume (CTV) delineation for cT2
rectal cancer treated with organ preservation. Materials and methods A systematic review …