Alchemical free energy simulations for biological complexes: powerful but temperamental…
A Aleksandrov, D Thompson… - Journal of Molecular …, 2010 - Wiley Online Library
Free energy simulations compare multiple ligand: receptor complexes by “alchemically”
transforming one into another, yielding binding free energy differences. Since their …
transforming one into another, yielding binding free energy differences. Since their …
Using data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and …
Over recent years, human pharmaceuticals have been detected in the aquatic environment.
This, combined with the fact that many are (by design) biologically active compounds, has …
This, combined with the fact that many are (by design) biologically active compounds, has …
BMP6 binding to heparin and heparan sulfate is mediated by N-terminal and C-terminal clustered basic residues
Background The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the
peptide hormone that regulates the iron availability in our body. Hepcidin expression is …
peptide hormone that regulates the iron availability in our body. Hepcidin expression is …
Methods of high throughput biophysical characterization in biopharmaceutical development
VI Razinkov, MJ Treuheit… - Current drug discovery …, 2013 - ingentaconnect.com
Discovery and successful development of biopharmaceutical products depend on a
thorough characterization of the molecule both before and after formulation …
thorough characterization of the molecule both before and after formulation …
Interferometric silicon biochips for label and label‐free DNA and protein microarrays
M Cretich, MR Monroe, A Reddington, X Zhang… - …, 2012 - Wiley Online Library
Protein and DNA microarrays hold the promise to revolutionize the field of molecular
diagnostics. Traditional microarray applications employ labeled detection strategies based …
diagnostics. Traditional microarray applications employ labeled detection strategies based …
A biofunctional polymeric coating for microcantilever molecular recognition
G Oliviero, P Bergese, G Canavese, M Chiari… - Analytica chimica …, 2008 - Elsevier
An innovative route to activate silicon microcantilevers (MCs) for label free molecular
recognition is presented. The method consists in coating the underivatized MCs with a …
recognition is presented. The method consists in coating the underivatized MCs with a …
Nanomechanical Recognition of N-Methylammonium Salts
M Dionisio, G Oliviero, D Menozzi… - Journal of the …, 2012 - ACS Publications
Turning molecular recognition into an effective mechanical response is critical for many
applications ranging from molecular motors and responsive materials to sensors. Herein, we …
applications ranging from molecular motors and responsive materials to sensors. Herein, we …
[HTML][HTML] 基于微流控技术的细胞水平高通量药物筛选系统的研究进展
Y LIANG, PAN Jianzhang, F Qun - Chinese Journal of …, 2021 - ncbi.nlm.nih.gov
药物筛选是新药研发的关键步骤, 创新药物的发现需要采用适当的药物作用靶点对大量化合物
样品进行筛选。 高通量筛选系统能够实现数千个反应同时测试和分析, 大大提高了药物筛选的 …
样品进行筛选。 高通量筛选系统能够实现数千个反应同时测试和分析, 大大提高了药物筛选的 …
Role of nanomechanics in canonical and noncanonical pro-angiogenic ligand/VEGF receptor-2 activation
Vascular endothelial growth factor receptor-2 (VEGFR2) is an endothelial cell receptor that
plays a pivotal role in physiologic and pathologic angiogenesis and is a therapeutic target …
plays a pivotal role in physiologic and pathologic angiogenesis and is a therapeutic target …
Research advances of high-throughput cell-based drug screening systems based on microfluidic technique
Y Liang, J Pan, Q Fang - Se pu= Chinese Journal of …, 2021 - europepmc.org
药物筛选是新药研发的关键步骤, 创新药物的发现需要采用适当的药物作用靶点对大量化合物
样品进行筛选. 高通量筛选系统能够实现数千个反应同时测试和分析, 大大提高了药物筛选的 …
样品进行筛选. 高通量筛选系统能够实现数千个反应同时测试和分析, 大大提高了药物筛选的 …