[HTML][HTML] Infections at the maternal–fetal interface: an overview of pathogenesis and defence

CJ Megli, CB Coyne - Nature Reviews Microbiology, 2022 - nature.com
Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

[HTML][HTML] Role of decidual natural killer cells in human pregnancy and related pregnancy complications

X Zhang, H Wei - Frontiers in immunology, 2021 - frontiersin.org
Pregnancy is a unique type of immunological process. Healthy pregnancy is associated with
a series of inflammatory events: implantation (inflammation), gestation (anti-inflammation) …

[HTML][HTML] Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

R Pique-Regi, R Romero, AL Tarca, F Luca, Y Xu… - Elife, 2020 - elifesciences.org
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million …

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

IA Stelzer, MS Ghaemi, X Han, K Ando… - Science translational …, 2021 - science.org
Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …

[HTML][HTML] Single nuclei RNA-seq of mouse placental labyrinth development

B Marsh, R Blelloch - Elife, 2020 - elifesciences.org
The placenta is the interface between mother and fetus in all eutherian species. However,
our understanding of this essential organ remains incomplete. A substantial challenge has …

[HTML][HTML] Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy

M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …

The maternal gut microbiome in pregnancy: implications for the developing immune system

O Koren, L Konnikova, P Brodin, IU Mysorekar… - Nature Reviews …, 2024 - nature.com
The gut microbiome has important roles in host metabolism and immunity, and microbial
dysbiosis affects human physiology and health. Maternal immunity and microbial …

[HTML][HTML] Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss

C Guo, P Cai, L Jin, Q Sha, Q Yu, W Zhang, C Jiang… - Cell discovery, 2021 - nature.com
Maintaining homeostasis of the decidual immune microenvironment at the maternal–fetal
interface is essential for placentation and reproductive success. Although distinct decidual …

Position statement from the International Society for Prenatal Diagnosis on the use of non‐invasive prenatal testing for the detection of fetal chromosomal conditions in …

L Hui, K Ellis, D Mayen, MD Pertile… - Prenatal …, 2023 - Wiley Online Library
Key points What is already known about this topic? In 2015, the International Society for
Prenatal Diagnosis (ISPD) published its first position statement on the use of non‐invasive …

[HTML][HTML] Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

V Garcia-Flores, R Romero, Y Xu, KR Theis… - Nature …, 2022 - nature.com
Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality.
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …