The bioinorganic chemistry of mammalian metallothioneins
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …
speculations since the discovery of the protein over 60 years ago. This article guides …
Cuproptosis: Harnessing transition metal for cancer therapy
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …
Self-Assembled Copper–Amino Acid Nanoparticles for in Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy
Nanoformulations that can respond to the specific tumor microenvironment (TME), such as a
weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer …
weakly acidic pH, low oxygen, and high glutathione (GSH), show promise for killing cancer …
[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies
X Wang, M Zhou, Y Liu, Z Si - Cancer Letters, 2023 - Elsevier
Recent studies have established a strong link between copper and cancer biology, as
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …
copper is necessary for cancer growth and metastasis. Beyond the conventional concept of …
Zinc transporters and their functional integration in mammalian cells
Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …
Copper homeostasis: Emerging target for cancer treatment
Y Li - IUBMB life, 2020 - Wiley Online Library
Copper (Cu) is an essential micronutrient involved in a variety of fundamental biological
processes. Recently, disorder of Cu homeostasis can be observed in many malignancies …
processes. Recently, disorder of Cu homeostasis can be observed in many malignancies …
Targeting copper in cancer therapy: 'Copper That Cancer'
Copper is an essential micronutrient involved in fundamental life processes that are
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …
conserved throughout all forms of life. The ability of copper to catalyze oxidation–reduction …
Mitochondrial copper in human genetic disorders
Copper is an essential micronutrient that serves as a cofactor for enzymes involved in
diverse physiological processes, including mitochondrial energy generation. Copper enters …
diverse physiological processes, including mitochondrial energy generation. Copper enters …
Self‐assembled copper‐based nanoparticles for glutathione activated and enzymatic cascade‐enhanced ferroptosis and immunotherapy in cancer treatment
As an emerging cancer treatment strategy, ferroptosis is greatly restricted by excessive
glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) …
glutathione (GSH) in tumor microenvironment (TME) and low reactive oxygen species (ROS) …