Regulation of microRNA (miRNA) expression has been extensively studied with respect to
colorectal cancer (CRC), since CRC is one of the leading causes of cancer mortality …

Over the past decade, research has shown that aberrant expression of microRNA (miRNA)
is involved in colorectal cancer development and progression. MicroRNAs are small …

Ninety-seven percent of drug-indication pairs that are tested in clinical trials in oncology
never advance to receive US Food and Drug Administration approval. While lack of efficacy …

Background The poor prognosis and rising incidence of esophageal adenocarcinoma
highlight the need for improved detection methods. The potential for circulating microRNAs …

Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …

MYC is a proto-oncogene that encodes a powerful regulator of transcription and cellular
programs essential for normal development, as well as the growth and survival of various …

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …

The PIM Kinases belong to the family of a proto-oncogene that essentially phosphorylates
the serine/threonine residues of the target proteins. They are primarily categorized into three …

Background PIM kinases are well-studied drug targets for cancer, belonging to
Serine/Threonine kinases family. They are the downstream target of various signaling …

PIM kinases, a serine/threonine kinase family with three isoforms, has been well-known to
participate in multiple physiological processes by phosphorylating various downstream …