Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of
death in the United States. Despite a profound upregulation in procoagulant mechanisms …

Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a
major challenge in the management of both surgical and seriously injured patients. Under …

Background Fibrinolysis is a physiologic process that maintains microvascular patency by
breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of …

Treatment of bleeding disorders using transfusion of donor-derived platelets faces logistical
challenges due to their limited availability, high risk of contamination, and short (5 to 7 days) …

BACKGROUND Trauma-induced coagulopathy (TIC) is associated with a fourfold increased
risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly …

Intravenous tranexamic acid (TXA) reduces death because of bleeding in patients with
trauma and postpartum haemorrhage. However, in some settings intravenous injection is not …

Acute Traumatic Coagulopathy occurs immediately after massive trauma when shock,
hypoperfusion, and vascular damage are present. Mechanisms for this acute coagulopathy …

The endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on
and within the vascular wall. It is mainly composed of a variety of proteoglycans and …

Further advances in TIC treatment require an enhanced understanding of the dynamic
changes in the equilibrium between pro and anticoagulant factors, downstream effectors …