Hydroxynitrile lyases (HNLs) primarily catalyze the stereoselective synthesis of
cyanohydrins, but some of them also carry out asymmetric nitroaldol synthesis (Henry …

Arabidopsis thaliana hydroxynitrile lyase (AtHNL) engineering has uncovered variants that
showed up to 12-fold improved catalytic efficiency than the wild-type towards asymmetric …

Chiral compounds are valuable industrial products and intermediates, and the production of
chemicals with high enantiopurity is one of the major objects in asymmetric catalysis …

Diastereoselective Henry reaction (DHR) is an effective direct C–C bond ligation
transformation that enables the synthesis of β-nitroalcohols having two contiguous chiral …

Protein engineering to improve promiscuous catalytic activity is important for biocatalytic
application of enzymes in green synthesis. We uncovered the significance of binding site …

Biocatalytic asymmetrization of inexpensive and stable primary alcohols to prepare
enantioenriched β‐nitroalcohols is an important development in green chemistry for the …

Novel chiral thiophene-2, 5-bis (β-amino alcohol) ligands (L1–L5) were designed and
synthesized from thiophene-2, 5-dicarbaldehyde (3) with chiral β-amino alcohols (4a–e) in 4 …

Granulicella tundricola hydroxynitrile lyase (Gt HNL) catalyses the synthesis of chiral (R)-
cyanohydrins and (R)-β-nitro alcohols. The triple variant Gt HNL-A40H/V42T/Q110H (Gt …

A single enzyme, Baliospermum montanum hydroxynitrile lyase (BmHNL), without alteration,
enabled bidirectional catalysis in enantiocomplementary synthesis of chiral β‐nitroalcohols …

Enantioselective CC Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-
catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new …