Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Changes in aging bone that lead to osteoporosis are mediated at multiple levels, including
hormonal alterations, skeletal unloading, and accumulation of senescent cells. This …

Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …

Bone metabolism is an intricate process involving various bone cells, signaling pathways,
cytokines, hormones, growth factors, etc., and the slightest deviation can result in various …

Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and
the functional decline of MSCs has emerged as a crucial pathophysiological driver of …

Bone metabolism consists of a balance between bone formation and bone resorption, which
is mediated by osteoblast and osteoclast activity, respectively. In order to ensure bone …

During bone marrow stromal cell (BMSC) differentiation, both Wnt signaling and the
development of a rigid cytoskeleton promote commitment to the osteoblastic over …

Craniofacial anomalies are among the most common of birth defects. The pathogenesis of
craniofacial anomalies frequently involves defects in the migration, proliferation, and fate of …

Background Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and
hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) …