The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …

ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

A protein module called the WW domain recognizes and binds to a short oligopeptide called
the PY motif, PPxY, to mediate protein–protein interactions. The PY motif is present in the …

▪ Abstract Ena/VASP proteins are a conserved family of actin regulatory proteins made up of
EVH1, EVH2 domains, and a proline-rich central region. They have been implicated in actin …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

Specific protein-protein interactions are involved in a large number of cellular processes and
are mainly mediated by structurally and functionally defined domains. Here we report that …

The ErbB-4 receptor protein-tyrosine kinase is proteolytically processed by membrane
proteases in response to the ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation …

WW domains are small protein modules composed of approximately 40 amino acids. These
domains fold as a stable, triple stranded β-sheet and recognize proline-containing ligands …

Pin1 contains an N-terminal WW domain and a C-terminal peptidyl-prolyl cis-trans
isomerase (PPIase) domain connected by a flexible linker. To address the energetic and …

▪ Abstract The low-density–lipoprotein (LDL) receptor family is an evolutionarily ancient
gene family of structurally closely related cell-surface receptors. Members of the family are …